Exosome Analysis Services for NanoSight Particle Analysis and EV Proteomics

Exosome analysis services delivering NTA, proteomics and small RNA characterisation data

Your exosome preparations go to contract laboratories for nanoparticle tracking, electron microscopy, or western blot analysis. This suits your projects that need characterisation data on a defined turnaround, without the capital cost of building NTA or mass spectrometry capacity in-house.

Nanoparticle tracking analysis (NTA) services give you size distribution histograms and particle concentration data. A fluorescent NTA variant labels EVs before analysis, to enrich the signal for labelled or marker-positive EV subsets. However, membrane dyes can also label non-EV lipid particles. You should interpret results alongside protein markers, contaminant markers, and the isolation method, rather than treat them as definitive vesicle identification.

LC-MS/MS-based exosome proteomics services cover total EV protein profiling. They return a protein identification list with quantification you can act on. The small RNA and miRNA sequencing analysis of EVs service profiles the small non-coding RNA cargo carried by your exosomes.

All services suit you if you need characterisation data to accompany a publication or regulatory submission, without investing in dedicated NTA or mass spectrometry infrastructure. Pricing is available on request, with a project quotation covering sample requirements, turnaround time, and data deliverables.

Choose your exosome analysis service by characterisation question and data type needed.

1. Particle size and concentration. Standard NTA service provides you with a size distribution histogram and mean particle diameter, plus concentration in particles per ml. It needs no fluorescence labelling, making it the fastest and lowest-cost characterisation option.

2. Particle identity confirmation. Fluorescent NTA service labels EVs with a tetraspanin antibody or membrane dye before NTA. This enriches the signal for labelled or marker-positive particles. Note that membrane dyes can label non-EV lipid particles, so you should interpret results alongside protein markers, contaminant controls, and isolation method.

3. Protein cargo profiling. LC-MS/MS total proteomics service: submit an EV pellet from your prep and receive a protein identification list. This suits biomarker discovery or comparing EV cargo between treatment groups.

4. Small RNA cargo profiling. Small RNA and miRNA sequencing analysis of EVs profiles the small non-coding RNA content of your exosome preparation. This is one of the most informative services for biomarker discovery, since circulating exosomal miRNAs are widely studied as disease biomarkers you can track.

5. Pricing and logistics. All services are priced on request, with current rates, sample submission guidelines, and turnaround time available on enquiry. Disclose the sample preparation method you used (ultracentrifugation, precipitation, or SEC) at submission.