Downstream assays such as RNA-seq, proteomics, and PCR amplification are sensitive to inhibitors, degradation products, and co-purified contaminants introduced during extraction. Low RNA integrity numbers (RIN below 7) reduce transcript coverage and bias differential expression data. Protein preparations contaminated with nucleic acids or detergents interfere with mass spectrometry. Consistent upstream preparation is the single most effective way to reduce batch effects.
Nucleic acid and protein purification kits, plus sample collection reagents, for reliable results
The sample preparation stage is where data quality is won or lost. Insufficient lysis, nuclease contamination, or poor stabilisation during collection introduces variability that no downstream assay can correct. Choosing the right preparation method for your sample type and downstream application is the single most important technical decision in any molecular workflow.
Nucleic Acid Purification covers spin-column and magnetic-bead kits for total RNA, genomic DNA, plasmid DNA, and cell-free circulating nucleic acids from plasma, serum, urine, and saliva. Protein Purification handles total protein extraction, subcellular fractionation, and organelle isolation using spin-column technology, so you avoid ultracentrifugation.
Sample Collection and Preservation provides ambient-temperature stabilisation formats for saliva, swab, stool, and liquid-biopsy specimens. You get room-temperature transport without dry ice. Sample Preparation Reagents and Accessories includes magnetic separators, lysis enhancers, Proteinase K, RNase R, and protease inhibitor cocktails, so you can support upstream workflows across every protocol.
Choosing the right sample preparation product
- Extracting nucleic acids. For total RNA, genomic DNA, plasmid DNA, or cell-free circulating nucleic acids from plasma, serum, urine, or saliva, you can use a Nucleic Acid Purification kit in spin-column or magnetic-bead format.
- Extracting or fractionating protein. For total protein extraction, subcellular fractionation, or organelle isolation without ultracentrifugation, you have a Protein Purification spin-column kit.
- Collecting or transporting samples. For saliva, swab, stool, or liquid-biopsy specimens that need to travel at ambient temperature without dry ice, you can rely on a Sample Collection and Preservation format.
- Supporting an existing protocol. For magnetic separators, lysis enhancers, Proteinase K, RNase R, or protease inhibitor cocktails to support any of the above workflows, you will find them in Sample Preparation Reagents and Accessories.
Applications
Genomics workflows
High-purity extraction from cells, tissue, blood and swab specimens, using nucleic acid purification kits, prepares your samples for RNA-seq and qPCR.
Proteomics and protein interaction studies
Subcellular fractionation isolates nuclear, cytoplasmic and membrane fractions for your western blotting, mass spectrometry or co-immunoprecipitation.
Biobanking and multisite clinical trials
Ambient-temperature sample collection and preservation formats preserve RNA and DNA integrity during transport, so you avoid cold-chain requirements.
Microbiome research
Field-collected specimens are stabilised at the point of collection, supporting your microbiome studies where fresh processing at a central laboratory is impractical.
Liquid biopsy and cell-free nucleic acid workflows
Magnetic-bead purification suits low-volume extraction of cfDNA and cfRNA from your plasma samples, and automates on liquid-handling platforms.
Protocol optimisation and troubleshooting
Magnetic separators, lysis enhancers, Proteinase K, RNase R and protease inhibitor cocktails from prep reagents and accessories support your workflows.
Product Categories
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Nucleic Acid Purification
Spin column, magnetic bead, and precipitation kits for isolating high-purity genomic DNA, plasmid DNA, and RNA.
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Protein Purification
Protein Extraction and Subcellular Fractionation Kits for Unbiased Samples
Sample Collection & Preservation
Sample Collection Tubes That Stabilise RNA and DNA Without Cold Chain
Sample Preparation Reagents & Accessories
Cell Lysis Buffers for Reproducible Protein and Nucleic Acid Extraction
Frequently asked questions
Spin-column methods use a silica membrane that binds nucleic acids under chaotropic conditions and releases them in low-salt elution buffer. They are fast and cost-effective for single samples. Magnetic-bead methods use paramagnetic particles that allow wash steps without centrifugation. This makes them automatable on liquid-handling platforms and better suited to high-throughput or low-volume inputs such as cfDNA from plasma.
RNA stabilisation reagents containing guanidinium thiocyanate or proprietary RNA-protective formulations can be added immediately at collection. They denature RNases and stabilise RNA at ambient temperature for several days. For tissue, immerse the sample in stabilisation reagent within 30 seconds of excision. For blood and saliva, dedicated collection tubes with built-in preservative allow room-temperature shipment.
The choice depends on the proteases present in your sample. Serine and cysteine protease inhibitors such as PMSF and a broad-spectrum cocktail are used routinely. For phosphoprotein studies, you must also include phosphatase inhibitors to maintain phosphorylation state. Metalloprotease inhibitors such as EDTA are included when divalent cation-dependent degradation is a concern.
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