SKU: T4436-1ml-TM
RO1138452
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Additional Information | RO1138452 is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1]. |
| Synonyms | CAY10441 |
| Purity | 95.73% |
Resources
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Datasheet
Catalog Number
T4436-1ml-TM
Name
RO1138452
Price(1 ml * 10 mM (in DMSO))
Pack Size