Bioactive Compounds

Bioactive small molecule compounds for targeted signalling pathway modulation

Switching a signalling pathway on or off with a small molecule lets you probe a target before you commit to a genetic approach. The range covers small molecule inhibitors and activators, enzyme inhibitors, kinase inhibitors, receptor modulators, and agonists and antagonists, acting on targets across Wnt, Hedgehog, Notch, JAK/STAT, PI3K/Akt/mTOR, MAPK/ERK and NF-kB, alongside epigenetic, apoptosis and autophagy modulators. Epigenetic tool compounds include Trichostatin A, a pan-HDAC inhibitor, and the milder pan-HDAC inhibitors Na Valproate and Phenylbutyrate Na. Every compound ships with a certificate of analysis from the manufacturer, so you can confirm purity and identity before you start.