A biochemicals range typically covers biological buffers (such as HEPES, MOPS, and Tris), inorganic salts, chelating agents, reducing agents, enzyme substrates, and solvents used in laboratory protocols. It may also include bioactive tool compounds and pre-formatted compound libraries for screening. Purity grades are specified for each item.
Products by Technology
Bioactive Compounds and Compound Libraries
Bioactive compounds and compound libraries for target validation, screening, and drug discovery
Two closely related ranges sit together here. Bioactive compounds are small molecule modulators with defined activity against a target. You use them to switch a signalling pathway on or off in cell-based and biochemical assays. Compound libraries are formatted collections of structurally diverse small molecules, ready for high-throughput screening and hit finding.
Around these two ranges sits a full set of research biochemicals: enzyme substrates and inhibitors, nucleotides and nucleosides, amino acids and peptides, lipids, carbohydrates, vitamins and coenzymes, detergents, buffers, and analytical reference standards. Together they support your enzyme assays, cell biology, and analytical workflows from bench to screen.
Narrowing down the right compound or library
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Single compound or library, and mechanism. Whether you need a single compound or a compound library depends on the biological mechanism, signalling pathway, or target class you want to study, for example a pathway inhibitor, activator, or enzyme inhibitor.
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Amount. How much material you need for assay development, screening, and follow-up studies determines the pack size or library format, with a safety margin for your planned experiments.
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Solubility and stability. The solubility and recommended solvents for your compounds are worth checking early. Your planned stock and working concentrations need to work with your assay, and storage conditions and stability matter for both individual compounds and library plates.
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Purity, CoA and QC data. The purity grade should fit your application, and certificates of analysis and QC data should match your planned setup. CoAs and detailed QC documentation are available on request.
Applications
Enzyme assay development
Enzyme substrates and inhibitors support kinetic characterisation, inhibitor screening, and mechanism-of-action studies across a wide range of enzyme classes.
Buffer and reagent preparation
Biological buffers, inorganic salts, chelating agents, and reducing agents cover the standard preparations needed for your routine molecular and cell biology protocols.
Signalling pathway research
Bioactive small molecule modulators of hot signalling pathways let you activate or block a specific target in cell-based and biochemical assays.
Nucleotide and nucleic acid biochemistry
Nucleotides and nucleosides support enzymatic reactions and complement PCR reagent workflows that need defined building blocks.
Analytical chemistry and QC
Reference standards, amino acids, peptides, and detergents support method validation, calibration, and quality control across your analytical workflows.
High-throughput screening and drug discovery
Compound libraries of structurally diverse small molecules, supplied in formatted plates, help identify active hits, stable, cell permeable and bioavailable, against a target of interest.
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Compound Libraries
Curated collections of bioactive and drug-like compounds for high-throughput screening and drug discovery campaigns.
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Bioactive Compounds
Small Molecule Compounds for Targeted Signalling Pathway Modulation
Frequently asked questions
Standard biochemical reagents, such as buffers, salts, and substrates, support general laboratory techniques. They are defined mainly by chemical purity. Bioactive compounds also have a defined biological activity, usually expressed as an IC50 or EC50 against a target. They are used to modulate biological pathways in assays or cell-based experiments.
A compound library is a collection of structurally diverse small molecules, supplied in a formatted plate, usually at a defined concentration in DMSO. In high-throughput screening (HTS), the library is tested against a target in a miniaturised assay to find active molecules. Fragment libraries, kinase-focused sets, screening libraries, and approved-drug collections each serve different discovery strategies.
Solvent choice affects compound solubility, stability, and biological compatibility. Prepare water-soluble compounds in aqueous buffer or water. Hydrophobic small molecules often need DMSO as a co-solvent. DMSO can affect membrane permeability and protein folding at higher concentrations. For this reason, keep the final assay concentration at or below 0.1% to avoid confounding effects.
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