SKU: IGR-R52H3-100ug-AC
Rhesus macaque IGF-I R / IGF-1 R Protein, His Tag (MALS verified)
Rhesus macaque
Specifications
| Specification | Details |
|---|---|
| Label | Unconjugated |
| Host | HEK293 |
| Molecular Weight | 81.1 kDa & 23.8 kDa |
| Tag | C-10×His |
| Purity | 90% |
| Endotoxin Level | 1.0 EU per μg |
| Format | Powder |
| Organism | Rhesus macaque |
| Accession No. | I2CWY3 |
| Sequence Info | Glu 31 - Asn 932 |
| Background | The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation. |
Resources
PDF
Datasheet
Catalog Number
IGR-R52H3-100ug-AC
Name
Rhesus macaque IGF-I R / IGF-1 R Protein, His Tag (MALS verified)
Price(100 ug)
Pack Size