SKU: PKSR030397-100ug-ELS
Recombinant Rat ICAM-1/CD54 Protein (His Tag)(Active)
Rat
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 52.7 kDa |
| Tag | C-His |
| Source | HEK293 Cells |
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per μg of the protein as determined by the LAL method |
| Activity | Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.When cells are added to rat ICAM1 coated plates (12.5 ¦Ìg/mL, 100 ¦ÌL/well), approximately > 30% cells will adhere specificall |
| Format | Lyophilized from sterile PBS, pH 7.4 |
| Synonyms | CD54;ICAM |
| Organism | Rat |
| Accession No. | Q00238-1 |
| Sequence Info | Met 1-Thr 493 |
| Background | Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity. |
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Datasheet
Catalog Number
PKSR030397-100ug-ELS
Name
Recombinant Rat ICAM-1/CD54 Protein (His Tag)(Active)
Price(10000 ug)
Pack Size
10000 ug