SKU: RPC23131-20-BM
Recombinant Rat CMRF35-like molecule 1 (Cd300lf), Partial
Rat (Rattus norvegicus)
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 38.3kDa |
| Tag | N-Terminal 10Xhis-Sumo-Tagged And C-Terminal Myc-Tagged |
| Source | E. coli |
| Purity | >90% by SDS-PAGE |
| Endotoxin Level | Not Tested |
| Synonyms | CD300 antigen-like family member FCD_antigen: CD300f |
| Organism | Rat (Rattus norvegicus) |
| Accession No. | Q566E6 |
| Sequence Info | Extracellular Domain 19~181aa |
| Background | Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4) . Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. |
Catalog Number
RPC23131-20-BM
Name
Recombinant Rat CMRF35-like molecule 1 (Cd300lf), Partial
Price(20 ug)
Pack Size