SKU: PDER100136-1mg-ELS
Recombinant Rat CCL20/MIP-3α Protein(Trx Tag)
Rat
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 27.6 kDa |
| Tag | N-Trx |
| Source | E.coli |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 10 EU/mg of the protein as determined by the LAL method. |
| Format | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Synonyms | CCL;CKb;Scya;CKb4;LARC;MIP3A;Scya20;St38;Ccl20 |
| Organism | Rat |
| Accession No. | P97884 |
| Sequence Info | Ser27-Met96 |
| Background | Chemokine (C-C motif) ligand 20 (CCL20/MIP-3α) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA). MIP3A / CCL20/MIP-3α is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of MIP3A / CCL20/MIP-3α has been seen in thymus, prostate, testis, small intestine and colon. As a chemotactic factor, MIP3A / CCL20/MIP-3α attracts lymphocytes and, slightly, neutrophils, but not monocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Its C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Chemokine CCL20/MIP-3α was shown to play a role in colorectal cancer (CRC) pathogenesis. |
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Catalog Number
PDER100136-1mg-ELS
Name
Recombinant Rat CCL20/MIP-3alpha Protein(Trx Tag)
Price(100 mg)
Pack Size