SKU: PKSM040585-200ug-ELS
Recombinant Mouse Activin RIIA/ACVR2A Protein (His & Fc Tag)(Active)
Mouse
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 41.4 kDa |
| Tag | C-His-Fc |
| Source | HEK293 Cells |
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Activity | Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 20-60 ng/mL in the presence of 10 ng/mL recombinant Activin A. |
| Format | Lyophilized from sterile PBS, pH 7.4 |
| Synonyms | ActrIIa;Acvr2;TactrII |
| Organism | Mouse |
| Accession No. | NP_031422.3 |
| Sequence Info | Met 1-Pro 134 |
| Background | ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways. |
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Datasheet
Catalog Number
PKSM040585-200ug-ELS
Name
Recombinant Mouse Activin RIIA/ACVR2A Protein (His & Fc Tag)(Active)
Price(20000 ug)
Pack Size
20000 ug