SKU: PKSH031028-100ug-ELS
Recombinant Human USP7/HAUSP Protein (aa 208-560)
Human
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 41 kDa |
| Source | Baculovirus-Insect Cells |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg as determined by the LAL method. |
| Format | Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, pH 8.0 |
| Synonyms | HAUSP;TEF1 |
| Organism | Human |
| Accession No. | NP_003461.2 |
| Sequence Info | Lys 208-Glu 560 |
| Background | Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein which belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 stimulates lytic infection and the reactivation of quiescent viral genomes. ICP0 interacts very strongly with USP7. USP7-mediated stabilization of ICP0 is dominant over ICP0-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP0-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP0 are expressed. |
Resources
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Datasheet
Catalog Number
PKSH031028-100ug-ELS
Name
Recombinant Human USP7/HAUSP Protein (aa 208-560)
Price(100 ug)
Pack Size
100 ug