SKU: RPC20839-20-BM
Recombinant Human Thioredoxin-interacting protein (TXNIP)
Human (Homo sapiens)
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 57.7kDa |
| Tag | N-Terminal 6Xhis-B2M-Tagged |
| Source | In Vitro E. coli Expression System |
| Purity | >90% by SDS-PAGE |
| Endotoxin Level | Not Tested |
| Synonyms | Thioredoxin-binding protein 2Vitamin D3 up-regulated protein 1 |
| Organism | Human (Homo sapiens) |
| Accession No. | Q9H3M7 |
| Sequence Info | Full Length 1~391aa |
| Background | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) . |
Catalog Number
RPC20839-20-BM
Name
Recombinant Human Thioredoxin-interacting protein (TXNIP)
Price(20 ug)
Pack Size