SKU: PKSH030762-50ug-ELS
Recombinant Human SerpinB4 Protein (His Tag)
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 47.1 kDa |
| Tag | N-His |
| Source | Baculovirus-Insect Cells |
| Purity | > 88 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg of the protein as determined by the LAL method. |
| Format | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 20% gly, 1mM EDTA, 1mM DTT |
| Synonyms | LEUPIN;PI11;SCCA-2;SCCA1;SCCA2 |
| Organism | Human |
| Accession No. | P48594 |
| Sequence Info | Met 1-Pro 390 |
| Background | Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. |
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Datasheet
Catalog Number
PKSH030762-50ug-ELS
Name
Recombinant Human SerpinB4 Protein (His Tag)
Price(5000 ug)
Pack Size
5000 ug