SKU: PKSH031788-100ug-ELS
Recombinant Human S100B Protein (His Tag)(Active)
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Tag | N-His |
| Source | E.coli |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | Please contact us for more information. |
| Activity | 1. Measured by its ability to bind human AGER in a functional ELISA.2. Measured by its ability to bind TP53 in a functional ELISA. |
| Format | Lyophilized from sterile PBS, 10% glycerol, pH 7.5 |
| Synonyms | Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100b; S100 beta; S100 calcium binding protein B;NEF;S100;S100-B;S100beta |
| Organism | Human |
| Accession No. | NP_006263.1 |
| Sequence Info | Ser 2-Glu 92 |
| Background | S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation; which might have important implications during brain; cartilage and skeletal muscle development and repair; activation of astrocytes in the course of brain damage and neurodegenerative processes; and of cardiomyocyte remodeling after infarction; as well as in melanomagenesis and gliomagenesis. As an extracellular factor; S100B engages RAGE (receptor for advanced glycation end products) in a variety of cell types with different outcomes (i.e. beneficial or detrimental; pro-proliferative or pro-differentiative) depending on the concentration attained by the protein; the cell type and the microenvironment. This calcium binding astrocyte-specific cytokine; presents a marker of astrocytic activation and reflects CNS injury. The excellent sensitivity of S100B has enabled it to confirm the existence of subtle brain injury in patients with mild head trauma; strokes; and after successful resuscitation from cardiopulmonary arrest. Recent findings provide evidence; that S100B may decrease neuronal injury and/or contribute to repair following traumatic brain injury (TBI). Hence; S100B; far from being a negative determinant of outcome; as suggested previously in the human TBI and ischemia literature; is of potential therapeutic value that could improve outcome in patients who sustain various forms of acute brain damage. |
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Datasheet
Catalog Number
PKSH031788-100ug-ELS
Name
Recombinant Human S100B Protein (His Tag)(Active)
Price(10000 ug)
Pack Size
10000 ug