SKU: PDEH100557-1mg-ELS
Recombinant Human S100A1 Protein(Trx Tag)
Human
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 30.3 kDa |
| Tag | N-Trx |
| Source | E.coli |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 10 EU/mg of the protein as determined by the LAL method. |
| Format | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Synonyms | Bpb;NEF;Protein S100-A1;S-100 protein alpha chain;S-100 protein subunit alpha;S100 alpha;S100 beta;S100 calcium binding protein A1;S100 calcium binding protein B;S100 calcium-binding protein A1;S100 protein alpha polypeptide;S100A;s100a1;S100B;S100beta;S10A1 |
| Organism | Human |
| Accession No. | P23297 |
| Sequence Info | Met1-Ser94 |
| Background | Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole. |
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Datasheet
Catalog Number
PDEH100557-1mg-ELS
Name
Recombinant Human S100A1 Protein(Trx Tag)
Price(100 mg)
Pack Size