SKU: Z100779-ABM
Recombinant Human PTH
Human
RT
Specifications
| Specification | Details |
|---|---|
| Gene Symbol | PTH |
| Molecular Weight | 9 |
| Source | E. coli |
| Purity | >95% as determined by SDS-PAGE |
| Activity | The ED(50) was determined by the dose-dependent proliferation of Immortalized Human Osteoblasts- SV40 and was found to be <0.5ng/mL. |
| Format | Lyophilized Powder |
| Synonyms | PTH, Parathormone, Parathyrin. Recombinant Human Parathyroid Hormone (PTH) |
| Organism | Human |
| Gene ID | 5741 |
| Accession No. | P01270 |
| Background | Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes. |
Catalog Number
Z100779-ABM
Name
Recombinant Human PTH
Price(2 mg)
Pack Size