SKU: PKSH032906-10ug-ELS
Recombinant Human PDGF-BB Protein (Active)
Human
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 12.4 kDa |
| Source | E.coli |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg as determined by the LAL method. |
| Activity | Measured in a cell proliferation assay using BALB/c 3T3 cells. The ED50 for this effect is 15-60ng/ml. |
| Format | Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
| Synonyms | Platelet-Derived Growth Factor Subunit B; PDGF Subunit B; PDGF-2; Platelet-Derived Growth Factor B Chain; Platelet-Derived Growth Factor Beta Polypeptide; Proto-Oncogene c-Sis; Becaplermin; PDGFB; PDGF2; SIS |
| Organism | Human |
| Accession No. | P01127 |
| Sequence Info | Ser82-Thr190 |
| Background | Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. |
Resources
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Datasheet
Catalog Number
PKSH032906-10ug-ELS
Name
Recombinant Human PDGF-BB Protein (Active)
Price(10 ug)
Pack Size