SKU: PDEH100754-100ug-ELS
Recombinant Human MIF protein(GST tag)
Human
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 38.3 kDa |
| Tag | N-GST |
| Source | E.coli |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 10 EU/mg of the protein as determined by the LAL method. |
| Format |
Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Synonyms | GIF;Glycosylation-inhibiting factor;L-dopachrome isomerase;L-dopachrome tautomerase;Phenylpyruvate tautomerase |
| Organism | Human |
| Accession No. | P14174 |
| Sequence Info | Pro2-Ala115 |
| Background | Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine, the effect of which on arresting random immune cell movement was recognized several decades ago. Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment. MIF is a ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. Further research has shown that MIF plays a particularly critical part in cell cycle regulation and therefore in tumorigenesis as well. The significance of the role of MIF in a variety of both solid and hematologic tumors has been established. More recently, interest has increased in the role of MIF in the development of the central nervous system (CNS) tumors, in which it appears to influence cell cycle control. MIF contributes to malignant disease progression on several different levels. Both circulating and intracellular MIF protein levels are elevated in cancer patients and MIF expression reportedly correlates with stage, metastatic spread, and disease-free survival. Blockade of MIF bioactivity successfully inhibited tumor cell growth in vivo and in vitro. MIF plays important role in the pathogenesis of gastrointestinal, hepatic, and pancreatic disorders. |
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Datasheet
Catalog Number
PDEH100754-100ug-ELS
Name
Recombinant Human MIF protein(GST tag)
Price(10000 ug)
Pack Size