SKU: PKSH031698-100ug-ELS
Recombinant Human Galectin-8/LGALS8 Protein (GST Tag)(Active)
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 62.7 kDa |
| Tag | N-GST |
| Source | E.coli |
| Purity | > 76 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | Please contact us for more information. |
| Activity | Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 0.2-1 μg/ml. |
| Format | Lyophilized from sterile 50mM Tris, 0.1 M NaCl, pH 8.0 |
| Synonyms | Galectin-8; Gal-8; Po66 Carbohydrate-Binding Protein; Po66-CBP; Prostate Carcinoma Tumor Antigen 1; PCTA-1; LGALS8 |
| Organism | Human |
| Accession No. | AAF19370.1 |
| Sequence Info | Met 1-Trp 317 |
| Background | Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions. |
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Datasheet
Catalog Number
PKSH031698-100ug-ELS
Name
Recombinant Human Galectin-8/LGALS8 Protein (GST Tag)(Active)
Price(10000 ug)
Pack Size
10000 ug