SKU: PKSH033924-20ug-ELS
Recombinant Human Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated
Human
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 27.5 kDa |
| Tag | C-6His-Avi |
| Source | Human Cells |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg as determined by the LAL method. |
| Format | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Synonyms | Folate receptor alpha; FR-alpha; Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor; Ovarian tumor-associated antigen MOv18; FOLR1 |
| Organism | Human |
| Accession No. | P15328 |
| Sequence Info | Arg25-Ser234 |
| Background | Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation. |
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Datasheet
Catalog Number
PKSH033924-20ug-ELS
Name
Recombinant Human Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated
Price(20 ug)
Pack Size