SKU: RPC25918-1000-BM
Recombinant Human Epidermal growth factor receptor (EGFR), partial
Human (Homo sapiens)
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 22.2kDa |
| Tag | N-Terminal 10Xhis-Sumo-Tagged And C-Terminal Myc-Tagged |
| Source | E. coli |
| Purity | >85% by SDS-PAGE |
| Endotoxin Level | Not Tested |
| Synonyms | Proto-oncogene c-ErbB-1Receptor tyrosine-protein kinase erbB-1ERBB, ERBB1, HER1 |
| Organism | Human (Homo sapiens) |
| Accession No. | P00533 |
| Sequence Info | Partial 669~684aa |
| Background | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity) . |
Catalog Number
RPC25918-1000-BM
Name
Recombinant Human Epidermal growth factor receptor (EGFR), partial
Price(1 mg)
Pack Size