SKU: PKSH033691-10ug-ELS
Recombinant Human ECE1 Protein (His Tag)
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 78.8 kDa |
| Tag | N-His |
| Source | Human Cells |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per μg as determined by the LAL method. |
| Format | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Synonyms | Endothelin-converting enzyme 1; ECE-1 |
| Organism | Human |
| Accession No. | P42892 |
| Sequence Info | Gln90-Trp770 |
| Background | Endothelin-Converting Enzyme-1 (ECE-1) is a single-pass type I I transmembrane (TM) protein with a short cytoplasmic tail and a large ectodomain. ECE-1 is a zinc protease of the neprilysin (NEP) family, which also includes ECE-2, PEX, XCE, DINE, and Kell, and several NEP-like proteins. It is widely expressed and has several alternatively spliced forms that differ in their TM domain or cytoplasmic tail. All isoforms of ECE-1 are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Endothelin-converting enzyme-1 is involved in the proteolytic processing of Endothelin-1 (EDN1), Endothelin-2 (EDN2), and Endothelin-3 (EDN3) to biologically active peptides. Defects in ECE1 are a cause of Hirschsprung disease, cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. |
Resources
PDF
Datasheet
Catalog Number
PKSH033691-10ug-ELS
Name
Recombinant Human ECE1 Protein (His Tag)
Price(1000 ug)
Pack Size