SKU: PKSH031762-50ug-ELS
Recombinant Human ECE-2 Protein (Fc Tag)
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 105 kDa |
| Tag | N-Fc |
| Source | HEK293 Cells |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg as determined by the LAL method. |
| Format | Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5 |
| Synonyms | ECE2;hCG_2022032;KIAA0604;MGC17664;MGC2408;MGC78487 |
| Organism | Human |
| Accession No. | NP_055508.3 |
| Sequence Info | Gly 199-Trp 883 |
| Background | Endothelin-converting enzyme 2; also known as ECE-2; is a metalloprotease that possesses many properties consistent with it being a neuropeptide-processing enzyme. Endothelin-converting enzymes (ECEs) are the key enzymes in the endothelin (ET) biosynthesis that catalyze the conversion of big ET; the biologically inactive precursor of mature ET. Two enzymes; termed ECE-1 and ECE-2; have been molecularly identified. ECE-2 is found primarily in neural tissues; with high levels of expression in midbrain; cerebellum; hypothalamus; frontal cortex and spinal cord and moderate levels in hippocampus and striatum. ECE-2 is strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). ECE-2 converts big endothelin-1 to endothelin-1. It is involved in the processing of various neuroendocrine peptides; including neurotensin; angiotensin I; substance P; proenkephalin-derived peptides; and prodynorphin-derived peptides. ECE-2 may limit beta-amyloid peptide accumulation in brain. It may also have methyltransferase activity. A comparison of residues around the cleavage site revealed that ECE-2 exhibits a unique cleavage site selectivity that is related to but distinct from that of ECE-1. |
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Datasheet
Catalog Number
PKSH031762-50ug-ELS
Name
Recombinant Human ECE-2 Protein (Fc Tag)
Price(5000 ug)
Pack Size
5000 ug