SKU: PKSH032359-50ug-ELS
Recombinant Human DFFA Protein (His Tag)
Human
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 38.7 kDa |
| Tag | N-6His |
| Source | E.coli |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg as determined by the LAL method. |
| Format | Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| Synonyms | DNA Fragmentation Factor Subunit Alpha; DNA Fragmentation Factor 45 kDa Subunit; DFF-45; Inhibitor of CAD; ICAD; DFFA; DFF1; DFF45; H13 |
| Organism | Human |
| Accession No. | O00273 |
| Sequence Info | Met 1-Thr331 |
| Background | DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. |
Resources
PDF
Datasheet
Catalog Number
PKSH032359-50ug-ELS
Name
Recombinant Human DFFA Protein (His Tag)
Price(5000 ug)
Pack Size