SKU: PDMH100391-500ug-ELS
Recombinant Human Coagulation Factor XIII B chain/F13B protein (His tag)
Human
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 72.6 kDa |
| Tag | C-His |
| Source | HEK293 Cells |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU/mg of the protein as determined by the LAL method. |
| Format |
Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Synonyms | Coagulation factor 13;Coagulation factor XIII;FXIIIB |
| Organism | Human |
| Accession No. | P05160 |
| Sequence Info | Met1-Thr661 |
| Background | Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 10 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Factor XIII acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Defects in F13B are the cause of factor XIII subunit B deficiency ( FA13BD ) which is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. |
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Datasheet
Catalog Number
PDMH100391-500ug-ELS
Name
Recombinant Human Coagulation Factor XIII B chain/F13B protein (His tag)
Price(50000 ug)
Pack Size