SKU: PKSH034029-50ug-ELS
Recombinant Human CD68/SR-D1 (C-Fc)
Human
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 58.5 kDa |
| Tag | C-Fc |
| Source | Human Cells |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg as determined by the LAL method. |
| Format | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Synonyms | CD68 antigenmacrophage antigen CD68; CD68 molecule; CD68; gp110; Macrosialin; SCARD1; SRD1; SR-D1 |
| Organism | Human |
| Accession No. | P34810 |
| Sequence Info | Asn22-Ile320 |
| Background | CD68, also called Scavenger Receptor D1 (SR-D1) and LAMP-4, is a heavily glycosylated type I transmembrane glycoprotein that belongs to the LAMP family. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. CD68 is also a biomarker of rheumatoid arthritis and Hodgkin's lymphoma. CD68 influences the functions of cells through NF-kB/focal adhesion kinase pathway (7). In addition, CD68 on macrophages binds tightly to both S100A8 and S100A9 to enhance the cell immunity. |
Resources
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Datasheet
Catalog Number
PKSH034029-50ug-ELS
Name
Recombinant Human CD68/SR-D1 (C-Fc)
Price(50 ug)
Pack Size