SKU: PKSH030979-100ug-ELS
Recombinant Human C1QBP Protein (aa 75-282, His Tag)
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 24.8 kDa |
| Tag | C-His |
| Source | E.coli |
| Purity | > 96 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | Please contact us for more information. |
| Format | Lyophilized from sterile PBS, pH 7.4 |
| Synonyms | Complement Component 1 Q Subcomponent-Binding Protein Mitochondrial; ASF/SF2-Associated Protein p32; Glycoprotein gC1qBP; C1qBP; Hyaluronan-Binding Protein 1; Mitochondrial Matrix Protein p32; gC1q-R Protein; p33; C1QBP; GC1QBP; HABP1; SF2P32;gC1qR |
| Organism | Human |
| Accession No. | NP_001203.1 |
| Sequence Info | His 75-Gln 282 |
| Background | Hyaluronan binding protein 1 (HABP1), also known as p32 or gC1qR, is a ubiquitously expressed multifunctional phospho-protein implicated in cell signalling. Hyaluronan-binding protein 1 (HABP1) /p32/gC1qR was characterized as a highly acidic and oligomeric protein, which binds to different ligands like hyaluronan, C1q, and mannosylated albumin. The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro. HABP1 overexpressing cells showed extensive vacuolation and reduced growth rate, which was corrected by frequent medium replenishment. Further investigation revealed that HABP1 overexpressing cells undergo apoptosis, and they failed to enter into the S-phase. The sperm surface HABP1 level can be correlated with the degree of sperm motility.Hyaluronan binding protein 1 (HABP1) was reported to be present on human sperm surface and its involvement in fertilization has already been elucidated: decreased HABP1 level may be associated with low motility of sperms, which in turn might cause infertility in the patient. HABP1 also is an endogenous substrate for MAP kinase and upon mitogenic stimulation it is translocated to the nucleus in a MAP kinase-dependent manner. |
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Datasheet
Catalog Number
PKSH030979-100ug-ELS
Name
Recombinant Human C1QBP Protein (aa 75-282, His Tag)
Price(10000 ug)
Pack Size
10000 ug