SKU: RPC22430-1000-BM
Recombinant Epstein-Barr virus Latent membrane protein 2 (LMP2), partial
Epstein-Barr virus (strain B95-8)(HHV-4)(Human herpesvirus 4)
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 31.6kDa |
| Tag | N-Terminal 6Xhis-Sumo-Tagged |
| Source | E. coli |
| Purity | >90% by SDS-PAGE |
| Endotoxin Level | Not Tested |
| Synonyms | Terminal protein |
| Organism | Epstein-Barr virus (strain B95-8)(HHV-4)(Human herpesvirus 4) |
| Accession No. | P13285 |
| Sequence Info | Partial 1~147aa |
| Background | Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.; FUNCTION |
Catalog Number
RPC22430-1000-BM
Name
Recombinant Epstein-Barr virus Latent membrane protein 2 (LMP2), partial
Price(1000 ug)
Pack Size