SKU: PKSR030511-100ug-ELS
Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)
SARS-CoV-2
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Molecular Weight | 36.79 kDa |
| Tag | N-6His |
| Source | E.coli |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per µg as determined by the LAL method. |
| Activity | Measured by its ability to cleave a fluorogenic peptide substrate, Arg-Leu-Arg-Gly-Gly-AMC (RLRGGAMC).The Specific Activity is >80pmols/min/μg |
| Format | Lyophilized from sterile 20 mM Tris 500mM NaCl, pH 7.4. |
| Synonyms | Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a |
| Organism | SARS-CoV-2 |
| Accession No. | YP_009725299.1 |
| Sequence Info | Glu1564-Val1880 |
| Background | The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells. |
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Datasheet
Catalog Number
PKSR030511-100ug-ELS
Name
Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)
Price(10000 ug)
Pack Size
10000 ug