SKU: CT4-R5259-1mg-AC
Rat CTLA-4 / CD152 Protein, Fc Tag
Rat
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Label | Unconjugated |
| Host | HEK293 |
| Molecular Weight | 40.2 kDa |
| Tag | C-Fc |
| Purity | 95% |
| Endotoxin Level | 1.0 EU per μg |
| Format | Powder |
| Synonyms | CTLA4,CD152 |
| Organism | Rat |
| Accession No. | Q62859 |
| Sequence Info | Ile 38 - Asp 161 |
| Background | CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis. |
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Catalog Number
CT4-R5259-1mg-AC
Name
Rat CTLA-4 / CD152 Protein, Fc Tag
Price(100 mg)
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