SKU: T201649-50mg-TM
PDL1 degrader-2
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Additional Information | PD-L1degrader-2 (Compound B3) is an orally effective AUTAC degrader that degrades PD-L1 via the autophagy-lysosome pathway with a DC50 of 0.5 μM. It inhibits the interaction between PD-1 and PD-L1, with an IC50 of 22.8 nM. PD-L1degrader-2 upregulates the expression of Atg9b, Lamp1, and Mitf, activating the autophagy-lysosome system. It exhibits antitumor activity in the CT26 mouse model. |
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Catalog Number
T201649-50mg-TM
Name
PDL1 degrader-2
Price(5000 mg)
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