SKU: T69081-25mg-TM
KRH-1636
Blue Ice
Specifications
| Specification | Details |
|---|---|
| CAS No. | 568526-77-2 |
| Additional Information | KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chemokine, stromal cell-derived factor 1alpha, to CXCR4 specifically and subsequent signal transduction. KRH-1636 prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor. KRH-1636 seems to be a promising agent for the treatment of HIV-1 infection. |
| Molecular Weight | 551,68 |
| Formula | C32H37N7O2 |
Resources
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Datasheet
Catalog Number
T69081-25mg-TM
Name
KRH-1636
Price(25 mg)
Pack Size