SKU: ILC-H5257-100ug-AC
Human IL-17 RA & IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Label | Unconjugated |
| Host | HEK293 |
| Molecular Weight | 60.0 kDa (IL-17 RA) & 75.7 kDa (IL-17 RC) |
| Tag | C-Fc | C-Fc |
| Purity | 95% |
| Endotoxin Level | 1.0 EU per μg |
| Format | Powder |
| Synonyms | IL-17 RA & IL-17 RC,IL-17RA & IL-17RC,CD217 & IL-17 RC |
| Organism | Human |
| Accession No. | Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC) |
| Sequence Info | Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) |
| Background | Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. |
Resources
PDF
Datasheet
Catalog Number
ILC-H5257-100ug-AC
Name
Human IL-17 RA & IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag
Price(10000 ug)
Pack Size