SKU: GR1-H52H3-100ug-AC
Human Gremlin / GREM1 Protein
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Label | Unconjugated |
| Host | HEK293 |
| Molecular Weight | 20.2 kDa |
| Tag | C-10×His |
| Purity | 95% |
| Endotoxin Level | 1.0 EU per μg |
| Format | Powder |
| Synonyms | GREM1,CKTSF1B1,DAND2,DRM,PIG2 |
| Organism | Human |
| Accession No. | NP_037504 |
| Sequence Info | Lys 25 - Asp 184 |
| Background | Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis. |
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Catalog Number
GR1-H52H3-100ug-AC
Name
Human Gremlin / GREM1 Protein
Price(10000 ug)
Pack Size