SKU: IL3-M82Q3-200ug-AC
Biotinylated Mouse IL-13 Protein, His,Avitag™ (MALS verified)
Mouse
Specifications
| Specification | Details |
|---|---|
| Label | Biotin-labeled |
| Host | HEK293 |
| Molecular Weight | 15.9 kDa |
| Tag | N-10×His & N-Avi |
| Purity | 90% |
| Format | Powder |
| Organism | Mouse |
| Accession No. | P20109 |
| Sequence Info | Ala 19 - Phe 131 |
| Background | Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction. |
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Datasheet
Catalog Number
IL3-M82Q3-200ug-AC
Name
Biotinylated Mouse IL-13 Protein, His,Avitag™ (MALS verified)
Price(200 ug)
Pack Size