SKU: HLN-H82E7-200ug-AC
Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Complex Protein (Monomer, MALS verified)
Human
RT
Specifications
| Specification | Details |
|---|---|
| Label | Biotin-labeled |
| Host | HEK293 |
| Molecular Weight | 36.3 kDa and 11.7 kDa |
| Tag | C-10×His & C-Avi |
| Purity | 90% |
| Format | Powder |
| Organism | Human |
| Accession No. | AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & LTLGEFLKL |
| Sequence Info | Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & LTLGEFLKL peptide |
| Background | The HLA-A*02:01&B2M&Survivin (LTLGEFLKL) complex is a key antigen-presenting complex in the immune system. HLA-A*02:01, a major histocompatibility complex (MHC) class I molecule, forms a stable heterodimer with β2-microglobulin (B2M). Subsequently, this dimer binds to the Survivin-derived peptide LTLGEFLKL—a specific epitope of Survivin, an anti-apoptotic protein overexpressed in various tumors. This complex is critical for activating cytotoxic T lymphocytes (CTLs), enabling the immune system to recognize and eliminate tumor cells expressing Survivin. |
Resources
PDF
Datasheet
Catalog Number
HLN-H82E7-200ug-AC
Name
Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Complex Protein (Monomer, MALS verified)
Price(200 ug)
Pack Size