SKU: GUC-H82E9-200ug-AC
Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, His,Avitag™
Human
In Stock
RT
Specifications
| Specification | Details |
|---|---|
| Label | Biotin-labeled |
| Host | HEK293 |
| Molecular Weight | 49.6 kDa |
| Tag | C-10×His & C-Avi |
| Purity | 95% |
| Endotoxin Level | 0.1 EU per μg |
| Format | Powder |
| Synonyms | GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C |
| Organism | Human |
| Accession No. | P25092-1 |
| Sequence Info | Ser 24 - Gln 430 |
| Background | GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer. |
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Catalog Number
GUC-H82E9-200ug-AC
Name
Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, His,Avitag�
Price(20000 ug)
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