DMXAA

DMXAA is a STING (Stimulator of Interferon Genes) agonist selective for mouse STING. Intratumoral administration of DMXAA resulted in tumor regression and complete rejection in mouse xenografts. Tumor regression induced by DMXAA results from a cascade of cellular events which include disruption of tumor vasculature followed by the release of chemokines which trigger the recruitment of immune cells. DMXAA induced expression of IFN-beta resulting in a striking expansion of leukemia-specific T cells extending survival in two acute myeloid leukemia models.