Anti-COVID-19 Traditional Chinese Medicine Compound Library

A unique collection of 1147 monomers from 60 TCM plants, a powerful tool for anti-COVID-19 drug discovery, can be used for HTS and HCS screening.

During the treatment of Covid-19 in China, the intervention of traditional Chinese medicine (TCM) reduced the severe symptoms of patients and played significant role in the war against COVID-19. Multiple research studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. TCM could suppress endotoxin-induced cytotoxicity, kill the virus, reduce the virus' access to the cell and lower the incidence of a cytokine storm. To further support the research in modes of action of TCM in the treatment of COVID-19, we extracted 1147 bioactive components (monomers) from TCM prescriptions having therapeutic effect. This library collects monomers of diverse structures, such as Flavonoids, alkaloids, Polyphenols, Terpenes, ets., from TCM prescriptions of significant therapeutic effect on COVID-19 including Lonicera japonica Thunb., Forsythia suspensa, Scutellaria baicalensis Georgi, Bupleuri Radix, Agastache rugosa, Isatidis Radix, Rhodiola rosea, etc.