X-CLARITY™ Tissue Clearing System II
The X-CLARITY™ Tissue Clearing System II is an all-in-one, easy-to-use solution for electrophoretic tissue clearing. Its unique design accelerates the removal of lipids from tissues while preserving the structural integrity of the sample.
Product Description
The X-CLARITY™ Tissue Clearing System II is an all-in-one, easy-to-use solution for electrophoretic tissue clearing. Its unique design accelerates the removal of lipids from tissues while preserving the structural integrity of the sample. Clear a whole mouse brain in just 6 hours, outstanding 8 times faster than the original technology.
In ETC (electrophoretic tissue clearing) mode, platinum-plated electrodes generate an electric field to accelerate the removal of lipids from tissues in a highly efficient manner. Users can set tissue clearing conditions through a simple and intuitive touchscreen interface. A built-in temperature control system actively cools and heats buffer to maintain consistent buffer temperatures during clearing. Buffer is constantly circulated to ensure consistent buffering capacity, temperature control, and elimination of tissue clearing byproducts.
This advanced system ensures efficient, rapid, and consistent tissue clearing.
Features of the X-CLARITY™ Tissue Clearing System II
- Precise temperature control: Active buffer cooling and heating capacity, sensitive and accurate temperature sensor
- Uniform electric field: Platinum plated electrodes, constant current and constant voltage modes
- Compatible with multiple tissue types and sizes: Active and passive clearing modes, holders of various sizes available
- User-friendly setup: Simple touchscreen interface, ready-to-use clearing solution
What our customers say
- The X-Clarity saves a lot of time. We were able to image an entire set of brain and spinal cords in a relatively short amount of time. This allowed us to clearly see the benefit of the approaches we are having on spinal cord networks following an injury- It's a great device to save time for your research.
- The X-Clarity has actually been fundamental to the Data Brain Project, because without being able to clear tissues of the lipids, we would not be able to image deep into the brains. So we would not be able to extract that structural information that is so important to understand the function of mammalian brains. It has been a huge advantage and a great leap forward in imaging.
- Thanks to X-Clarity, we now have access to three dimensions of the whole heart organ.
Product Citations
- Simon-Chica A, Fernández MC, Wülfers EM, Lother A, Hilgendorf I, Seemann G, Ravens U, Kohl P, Schneider-Warme F (2022) Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels Cardiovasc Res. 118(3):798-813
- Humbel M, Ramosaj M, Zimmer V, Regio S, Aeby L, Moser S, Boizot A, Sipion M, Rey M, Déglon N (2021) Maximizing lentiviral vector gene transfer in the CNS Gene Therapy volume 28, pages75–88
- Louie A, Kim J, Soto-Diaz K, Dibaeinia P, Koito H, Sinha S, Nowak R, Das A, Steelman A (2021) Influenza causes alterations to oligodendrocyte-specific transcripts and the myelin lipidome in the adult mouse central nervous system Research Square
- Georgieva JV, Goulatis LI, Stutz CC, Canfield SG, Song HW, Gastfriend BD, Shusta EV (2020) Antibody screening using a human iPSC‐based blood‐brain barrier model identifies antibodies that accumulate in the CNS FASEB J
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C30001-LG - Supplier
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