Hi-C Structural Variant Detection

Hi-C-based structural variant detection for large rearrangements missed by short-read NGS

When you have very large structural variants (translocations, inversions, large deletions, complex rearrangements) that short-read NGS misses, Hi-C-based SV detection uses the chromatin-contact-frequency signature these variants produce.

Pick by sample and resolution.

1. Sample type. Cell line, fresh tissue, FFPE. FFPE has specific Hi-C protocols.
2. Resolution. Megabase versus subkilobase. Depends on sequencing depth.
3. Variant class. For variants below 10 kb short-read NGS or long-read sequencing outperforms Hi-C. Hi-C wins for very large rearrangements and balanced translocations.

Arima supplies structural variant Hi-C platforms.