Fiber-seq (Long-read Multiomic)

Fiber-seq reagents for long-read sequencing with single-molecule epigenetic and genetic profiling

When you want long-read sequencing with epigenetic-mark detection on the same DNA molecule, Fiber-seq combines PacBio or ONT long reads with chromatin accessibility or methylation profiles per molecule. Resolves haplotype-phased epigenetic and genetic variation at single-molecule resolution.

Pick by marks and platform.

1. Target marks. m6A-based accessibility marking versus methylation marks. Choose based on biological question.
2. Sequencing platform. PacBio HiFi versus ONT have specific compatibility.
3. Read length and accuracy. Match to your structural variant or regulatory variant question.
4. Sample input. Verify the protocol works at your scale.
5. Bioinformatics. Specialised pipelines required; verify support.

EpiCypher leads in Fiber-seq reagents. Technology is still emerging; start with established protocols on benchmark samples.