Exosome RNA & DNA Purification

Exosome RNA extraction kits for miRNA, mRNA and cfDNA

Standard total-RNA columns fall short when you need to preserve small-RNA fractions below 200 nt, which is where dedicated precipitation-plus-column workflows come in. These kits use Norgen's patented silica carbide membrane, which binds RNA of any size or GC content without bias, combining an initial EV enrichment step with spin-column purification tuned for exosomal miRNA isolation from serum or plasma. They work with EVs from any prior isolation method, whether precipitation, size-exclusion chromatography or immunoaffinity capture, and IZON qEV column users have a dedicated option: the Exosomal RNA Isolation Kit (for EVs isolated using IZON qEV columns), Cat#68910-NB. For cfDNA extraction from your EVs, combined RNA and DNA capture kits retain both nucleic acid species in a single workflow, avoiding the need for separate extractions.

Pick by starting material and downstream.

1. Starting material. Some kits accept biofluid directly. Others need pre-isolated exosome pellets.
2. Output species. For total RNA with small RNA retained, verify the kit holds fragments below 200 nt. For DNA-only use exosome-specific DNA kits.
3. Input volume. Biofluid kits handle milliliters. Cell-supernatant kits handle smaller volumes.
4. Downstream. For small-RNA NGS confirm small-RNA retention. For qPCR-ready RNA standard chemistry works.
5. Low-input. For scarce clinical samples choose kits validated for picogram-scale recovery.

Norgen Biotek for biofluid-direct exosome RNA and DNA kits. SBI System Biosciences for ExoQuick-based companion purification.