ChIP-seq Library Prep

ChIP-seq library prep kits for Illumina-compatible sequencing from low-input DNA

When you need NGS libraries from ChIP DNA input (nanograms), this section covers Illumina-compatible library prep with end-repair, A-tailing, adapter ligation, and amplification optimised for short, low-abundance fragments typical of ChIP.

Pick by input and indexing.

1. Input. Standard kits handle 1 to 10 ng. Low-input kits go to picograms for CUT&RUN-equivalent workflows.
2. Adapter and indexing. UDI dual-indexing for low cross-talk. Single-index for cost-sensitive routine.
3. PCR cycles. Over-amplification introduces duplicate reads and bias. Low-input kits minimise cycles.
4. Workflow length. Match to facility throughput needs.
5. Multiplex. For pooled sequencing at scale UDI is essential.

EpigenTek leads the ChIP-seq library prep catalogue with EpiNext-family kits.