SKU: TA306153-OR
TRIM5 alpha (TRIM5) Rabbit Polyclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | IF, WB |
| Label | Unconjugated |
| Synonyms | RNF88; TRIM5alpha |
| Gene ID | 574288 |
| UniProt ID | Q0PF16 |
| Background | TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has six alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission (3). |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA306153-OR
Name
TRIM5 alpha (TRIM5) Rabbit Polyclonal Antibody
Price(0.1 mg)
Pack Size
0.1 mg