SKU: TA306487-OR
TEM4 (ARHGEF17) Rabbit Polyclonal Antibody
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | IHC, WB |
| Label | Unconjugated |
| Synonyms | p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4 |
| Gene ID | 9828 |
| Accession No. | NM_014786 |
| UniProt ID | Q96PE2 |
| Background | Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA306487-OR
Name
TEM4 (ARHGEF17) Rabbit Polyclonal Antibody
Price(10 mg)
Pack Size
10 mg