SKU: TA301509-OR
TDP43 (TARDBP) Rabbit Polyclonal Antibody
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Primate, Mouse, Xenopus, Zebrafish, Chicken |
| Application | ELISA, ICC/IF, IHC, WB |
| Label | Unconjugated |
| Synonyms | ALS10; TDP-43 |
| Gene ID | 23435 |
| Accession No. | NM_007375 |
| UniProt ID | Q13148 |
| Background | The HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1 contains an RNA genome which produces chromosomally integrated DNA during cellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNA regulatory element TAR which is located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to the chromosomally integrated TAR DNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicing of the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in the post-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncection between these two diseases provides an explanation for the observed clinical overlap. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA301509-OR
Name
TDP43 (TARDBP) Rabbit Polyclonal Antibody
Price(10 ml)
Pack Size
10 ml