SKU: TA500040S-OR
Sonic Hedgehog (SHH) Mouse Monoclonal Antibody [Clone ID: OTI3A2]
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | IF, WB |
| Label | Unconjugated |
| Synonyms | HHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS |
| Gene ID | 6469 |
| Accession No. | NM_000193 |
| UniProt ID | Q15465 |
| Background | SHH is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG2a |
| Clone Name | OTI3A2 |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
PDF
Datasheet
Catalog Number
TA500040S-OR
Name
Sonic Hedgehog (SHH) Mouse Monoclonal Antibody [Clone ID: OTI3A2]
Price(30 ul)
Pack Size