SKU: E-AB-92465-200ul-ELS
SMC5 Polyclonal Antibody
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human,Mouse,Rat |
| Application | WB |
| Label | Unconjugated |
| Synonyms | SMC5,SMC5L1 |
| Gene ID | 23137 |
| UniProt ID | Q8IY18 |
| Immunogen | Recombinant fusion protein of human SMC5 |
| Background | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres cell lines and mediates sumoylation of shelterin complex (telosome components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
E-AB-92465-200ul-ELS
Name
SMC5 Polyclonal Antibody
Price(200 ul)
Pack Size