SKU: TA326587-OR
Slc12a3 Rabbit Polyclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | IF, WB |
| Label | Unconjugated |
| Synonyms | FLJ96318; NCCT; TSC |
| Gene ID | 54300 |
| Accession No. | NM_019345 |
| UniProt ID | P55018 |
| Background | NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis . Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1. In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC . Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension . Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat . |
| Primary / Secondary | Primary Antibody |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA326587-OR
Name
Slc12a3 Rabbit Polyclonal Antibody
Price(0.1 mg)
Pack Size
0.1 mg